Pregabalin and Gabapentin - are prescription drugs that may cause sedation. They are both misused for the same effects as benzodiazepines or alcohol. Mixing benzodiazepines or alcohol with Pregabalin and Gabapentin can result in drowsiness, sedation, respiratory depression and death. Pregabalin is a gabapentinoid and acts by inhibiting certain calcium channels. Despite the fact that pregabalin is a GABA analogue, it does not bind to the GABA receptors, does not convert into GABA or another GABA receptor agonist in vivo, and does not directly modulate GABA transport or metabolis. However, pregabalin may have some indirect GABAergic effects by increasing GABA levels in the brain.